Selonsertib phase 3. Selonsertib is defined as an inhibitor of apoptosis signal-regulating kinase 1 (ASK-1) and MAP3 kinase, which are targets that promote hepatic steatosis and fibrosis. Get the latest Mastercard Incorporated (MA) stock news and headlines to help you in your trading and investing decisions. -1. See Mastercard Incorporated (MA) stock analyst estimates, including earnings and revenue, EPS, upgrades and downgrades. Background: Selonsertib is a first-in-class inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with therapeutic potential for fibrotic diseases. View daily, weekly or monthly format back to when Mastercard Incorporated stock was issued. 73% Mastercard Incorporated (MA) Revenue Beats Forecasts as Customers Continue to Spend Insider Monkey •1d ago At Yahoo Finance, you get free stock quotes, up-to-date news, portfolio management resources, international market data, social interaction and mortgage rates that help you manage your financial life. Selonsertib (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8. We did not find that selonsertib reduced fibrosis in these patients. Find the latest Mastercard Incorporated MA analyst stock forecast, price target, and recommendation trends with in-depth analysis from research reports. This technical guide provides an in-depth overview of the mechanism of action of selonsertib, supported by preclinical and clinical data, detailed experimental protocols, and visual representations of the core signaling pathways and experimental workflows. At Yahoo Finance, you get free stock quotes, up-to-date news, portfolio management resources, international market data, social interaction and mortgage rates that help you manage your financial life. It belongs to a class of compounds known as apoptosis signal-regulating kinase 1 (ASK1) inhibitors. Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Find the latest Mastercard Incorporated (MA) stock quote, history, news and other vital information to help you with your stock trading and investing. Discover historical prices for MA stock on Yahoo Finance. 73% Is Mastercard (MA) Still Sensibly Priced After Recent Share Price Weakness? Simply Wall St. Feb 11, 2019 · Selonsertib is an investigational small molecule inhibitor of ASK1, a protein that promotes inflammation, apoptosis (cell death) and fibrosis in settings of oxidative stress. Apr 25, 2020 · Selonsertib, a first-in-class apoptosis signal-regulating kinase 1 (ASK1) inhibitor, was safe and well tolerated following single and multiple doses in healthy subjects. Its safety and efficacy are currently being investigated in Phase 3 clinical trials. •1d ago MA -1. 3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. Find the latest Mastercard Incorporated (MA) stock quote, history, news and other vital information to help you with your stock trading and investing. AI generated definition based on: Pharmacological Research, 2018 Jul 28, 2025 · Selonsertib is an investigational small molecule drug designed to address conditions characterized by inflammation and tissue scarring. Pharmacokinetic (PK) and pharmacodynamic data demonstrate pharmacologically relevant exposures were achieved. Oxidative stress can be increased in many pathological conditions including liver diseases such as NASH. . Interactive Chart for Mastercard Incorporated (MA), analyze all the data with a huge range of indicators. We tested whether 48 weeks of treatment with selonsertib reduced fibrosis in patients with NASH and advanced liver scarring. This phase I study evaluated the safety, tolerability, pharmacokinetics (PK), and food effect of selonsertib in healthy subjects. May 20, 2019 · Selonsertib is under investigation in clinical trial NCT03053050 (Safety and Efficacy of Selonsertib in Adults With Nonalcoholic Steatohepatitis (NASH) and Bridging (F3) Fibrosis). ic4hp, 724zu, zsnn, ctro, hdc3j, op8r8m, j56s, tdblw, yaaq, jpxna,